Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-nitropyridine

HRID 413756Notes

Reaction equation

HRID 413756 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>C(O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:12][NH2:13])=[N:3][CH:4]=1)([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 783082-Chloro-5-nitropyridine

Product 1

HCID 40319312-Hydrazinyl-5-nitropyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 2-chloro-5-nitropyridine (30 mmol, 5.0 g) in absolute ethanol was added a solution of hydrazine hydrate (320 mmol, 15.8 g) in ethanol using syringe pump. At the end of the addition, the reaction was refrigerated. The named product precipitated from the reaction medium, was collected by filtration, and recrystallized from ethanol.

Workup

  1. additionAt the end of the addition
  2. customThe named product precipitated from the reaction medium
  3. filtrationwas collected by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-20e2d9eb9813449e826a5a22025ef6e4
Source dataset
uspto-grants-2003_05
Patent number
US06569885B1

Reaction notes

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