反应详情

A mixture of 5-[4-(6-methoxy-1-methyl-1H-benzimidazol-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (10.6 g) and 4N hydrochloric acid in 1,4-dioxane (100 ml) was stirred at room temperature for 1 hour. The reaction mixture was concentrated, and to the residue was added ethyl acetate to form a precipitate. The precipitate was collected by filtration and washed with ethyl acetate to afford the title compound (11.0 g).

1. concentrationThe reaction mixture was concentrated
2. additionto the residue was added ethyl acetate
3. customto form a precipitate
4. filtrationThe precipitate was collected by filtration
5. washwashed with ethyl acetate