Hydrochloric Acid → HCID 86585958, compound

HRID 413776Notes

Reaction equation

HRID 413776 reaction equation
C(OC(=O)[N:7]([C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[NH:23][C:24](=O)[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][CH:34]2[S:38][C:37](=[O:39])[NH:36][C:35]2=[O:40])=[CH:29][CH:28]=1)[CH3:8])(C)(C)C.[ClH:43]>O1CCOCC1>[ClH:43].[CH2:16]([O:15][C:13]1[CH:12]=[CH:11][C:10]2[N:23]=[C:24]([CH2:25][O:26][C:27]3[CH:28]=[CH:29][C:30]([CH2:33][CH:34]4[S:38][C:37](=[O:39])[NH:36][C:35]4=[O:40])=[CH:31][CH:32]=3)[N:7]([CH3:8])[C:9]=2[CH:14]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15541462HCID 15541462, compound

Product 1

HCID 86585958HCID 86585958, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N-[2-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-benzyloxyphenyl]-N-methylcarbamic acid t-butyl ester (4.27 g) (obtained in Example 2-1) was dissolved in 4N hydrochloric acid in dioxane (30 ml) and the resulting mixture was allowed to stand at room temperature for 19 hours. The reaction mixture was concentrated and to the residue was added ethyl acetate to form crystals. The crystals were washed with ethyl acetate and dried in vacuo to afford the title compound (4.27 g).

Workup

  1. concentrationThe reaction mixture was concentrated and to the residue
  2. additionwas added ethyl acetate
  3. customto form crystals
  4. washThe crystals were washed with ethyl acetate
  5. customdried in vacuo

Sources & evidence

ORD record
ord-17e40be8911a4d6a8c7052b011f331bc
Source dataset
uspto-grants-2003_05
Patent number
US06569877B2

Reaction notes

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