Hydrochloric Acid → HCID 86585960, compound

HRID 413778Notes

Reaction equation

HRID 413778 reaction equation
C(OC(=O)[N:7]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[NH:16][C:17](=O)[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]2[S:31][C:30](=[O:32])[NH:29][C:28]2=[O:33])=[CH:22][CH:21]=1)[CH3:8])(C)(C)C.Cl>O1CCOCC1>[ClH:15].[Cl:15][C:13]1[CH:12]=[CH:11][C:10]2[N:16]=[C:17]([CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:26][CH:27]4[S:31][C:30](=[O:32])[NH:29][C:28]4=[O:33])=[CH:24][CH:25]=3)[N:7]([CH3:8])[C:9]=2[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86585959HCID 86585959, compound

Product 1

HCID 86585960HCID 86585960, compoundYield 183.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

N-[2-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-chlorophenyl]-N-methylcarbamic acid t-butyl ester (3.16 g) (obtained in Example 3-1) was dissolved in dioxane (30 ml). To the solution was added 4N hydrochloric acid in dioxane (30 ml) and the resulting mixture was stirred at room temperature for 3 hours and allowed to stand overnight. The reaction mixture was filtered and the crystals were washed with ethyl acetate and dried in vacuo to afford the title compound (2.44 g). softening point: 301-303° C.

Workup

  1. waitto stand overnight
  2. filtrationThe reaction mixture was filtered
  3. washthe crystals were washed with ethyl acetate
  4. customdried in vacuo

Sources & evidence

ORD record
ord-b83fbfbf2b4144b2922169d6ae77f3f9
Source dataset
uspto-grants-2003_05
Patent number
US06569877B2

Reaction notes

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