Hydrochloric Acid → HCID 88118033, compound

HRID 413780Notes

Reaction equation

HRID 413780 reaction equation
C(OC(=O)[N:7]([C:9]1[CH:14]=[C:13]([S:15][CH3:16])[CH:12]=[CH:11][C:10]=1[NH:17][C:18](=O)[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH:28]2[S:32][C:31](=[O:33])[NH:30][C:29]2=[O:34])=[CH:23][CH:22]=1)[CH3:8])(C)(C)C.[ClH:37]>O1CCOCC1>[ClH:37].[CH3:16][S:15][C:13]1[CH:12]=[CH:11][C:10]2[N:17]=[C:18]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]4[S:32][C:31](=[O:33])[NH:30][C:29]4=[O:34])=[CH:23][CH:22]=3)[N:7]([CH3:8])[C:9]=2[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88118032HCID 88118032, compound

Product 1

HCID 88118033HCID 88118033, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

N-[2-[4-(2,4-Dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-methylthiophenyl]-N-methylcarbamic acid t-butyl ester (2.54 g) (obtained in Example 4-1) was dissolved in dioxane (25 ml). To the solution was added 4N hydrochloric acid in dioxane (25 ml) and the resulting mixture was stirred for 30 minutes at room temperature and allowed to stand for two nights. The reaction mixture was filtered and the crystals were washed with ethyl acetate and dried in vacuo to afford the title compound (2.98 g). softening point: 247-249° C.

Workup

  1. waitto stand for two nights
  2. filtrationThe reaction mixture was filtered
  3. washthe crystals were washed with ethyl acetate
  4. customdried in vacuo

Sources & evidence

ORD record
ord-40776106d2c84c06b3978f4c69584941
Source dataset
uspto-grants-2003_05
Patent number
US06569877B2

Reaction notes

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