HRID413856

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22392950

未命名化合物

结构：C[C@H](N)C(=O)C1(N)N=C(c2ccccc2F)c2ccccc2N(C)C1=O

HCID69033619

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)C(C)(O)c1cc(F)cc(F)c1)C(=O)C1(N)N=C(c2ccccc2F)c2ccccc2N(C)C1=O

HCID86592590

未命名化合物

PROCEDURE

实验过程

Following General Procedure D above using 3,5-difluorophenyl-α-hydroxy-α-methylacetic acid (described above in Example 2-18) and 3-(L-alaninyl)-amino-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-Benzodiazepin-2-one (Example 8-b), the title compound was prepared.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9f50f6e9f5404449ab2756192b72599b
来源数据集: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06569851B1
来源说明: uspto-grants-2003_05

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([C:9]([OH:14])([CH3:13])[C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:15][C@H:16]([C:18]([C:20]1([NH2:40])[N:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[F:33])[C:24]2[CH:34]=[CH:35][CH:36]=[CH:37][C:23]=2[N:22]([CH3:38])[C:21]1=[O:39])=[O:19])[CH3:17]>>[F:8][C:6]1[CH:5]=[C:4]([C:9]([OH:14])([CH3:13])[C:10]([NH:15][C@H:16]([C:18]([C:20]2([NH2:40])[N:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[F:33])[C:24]3[CH:34]=[CH:35][CH:36]=[CH:37][C:23]=3[N:22]([CH3:38])[C:21]2=[O:39])=[O:19])[CH3:17])=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1