HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorophenyl-alpha-hydroxy-alpha-methylacetic acid → 3-[N'-(3,5-difluorophenyl-alpha-hydroxy-alpha-methylacetyl)-L-alaninyl]-amino-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-Benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorophenyl-alpha-hydroxy-alpha-methylacetic acid | HCID 22392950 | — |
| Reactant | 3-(L-alaninyl)-amino-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one | HCID 69033619 | — |
| Product | 3-[N'-(3,5-difluorophenyl-alpha-hydroxy-alpha-methylacetyl)-L-alaninyl]-amino-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-Benzodiazepin-2-one | HCID 86592590 | — |
Reaction Steps
Following General Procedure D above using 3,5-difluorophenyl-α-hydroxy-α-methylacetic acid (described above in Example 2-18) and 3-(L-alaninyl)-amino-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-Benzodiazepin-2-one (Example 8-b), the title compound was prepared.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06569851B1 |
| Source dataset | uspto-grants-2003_05 |
| ORD ID | ord-9f50f6e9f5404449ab2756192b72599b |
| Source note | uspto-grants-2003_05 |