Sodium borohydride → HCID 491837, compound

HRID 413922Notes

Reaction equation

HRID 413922 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=2)[C:7]=1[CH3:26])=[O:5])[CH3:2].[BH4-].[Na+]>CO.Cl[Ni]Cl>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=2)[C:7]=1[CH3:26])=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 9798485HCID 9798485, compound

Product 1

HCID 491837HCID 491837, compound

Reagents, catalysts & solvents 2

HCID 24385Nickel DichlorideCatalystHCID 887MethanolSolvent

Procedure

The compound of Example 22 (0.86 mmol, 0.3 g) was dissolved in methanol and treated with NiCl2 and NaBH4 (17.2 mmol) using the procedure set forth in Example 40. The named product was purified over silica (m.p. 142° C.-143° C.).

Workup

  1. customThe named product was purified over silica (m.p. 142° C.-143° C.)

Sources & evidence

ORD record
ord-06ba413ad5114898acc3404ccc4e0482
Source dataset
uspto-grants-2003_05
Patent number
US06569890B2

Reaction notes

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