反应详情

Cyclization of S-methylisothiourea sulfate (139 mg), 3-n-octyloxybenzaldehyde (338 mg) and ethyl cyanoacetate (112 μl), treatment of the product with POCl3 and subsequent reaction with ethyl 2-mercaptoacetate were performed according to the methods described in example 1. The pure title compound was obtained after chromatography on silicagel in dichloromethane/methanol=100/0 (v/v)→90/10 (v/v) as eluent.