2-Amino-4-methoxyphenol → 2-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one

HRID 414071노트

반응식

HRID 414071 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].Br[CH:12]([CH2:16][CH2:17][CH2:18][Br:19])[C:13](Cl)=[O:14]>>[Br:19][CH2:18][CH2:17][CH2:16][CH:12]1[C:13](=[O:14])[NH:1][C:2]2[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=2[O:10]1

참가 물질

3

반응물 2

HCID 14191082-Amino-4-methoxyphenolHCID 111850322,5-Dibromopentanoyl chloride

생성물 1

HCID 143046612-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one수율 56.9%

실험 절차

In a manner similar to that of Reference Example 16, 2-amino-4-methoxyphenol was allowed to react with 2,5-dibromovaleryl chloride, then cyclized to give 2-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one as crystals. The yield was 56.9%. m.p. 102°-103° C. (recrystallization from ether).

출처 및 근거

ORD 기록
ord-feb1a221669e4255be3a9b51651d3ac6
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04789675

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