HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methoxyphenol → 2-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methoxyphenol | HCID 1419108 | — |
| Reactant | 2,5-Dibromopentanoyl chloride | HCID 11185032 | — |
| Product | 2-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one | HCID 14304661 | 56.9% |
Reaction Steps
In a manner similar to that of Reference Example 16, 2-amino-4-methoxyphenol was allowed to react with 2,5-dibromovaleryl chloride, then cyclized to give 2-(3-bromopropyl)-6-methoxy-2H-1,4-benzoxazine-3(4H)-one as crystals. The yield was 56.9%. m.p. 102°-103° C. (recrystallization from ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04789675 |
| Source dataset | uspto-grants-1988_12 |
| ORD ID | ord-feb1a221669e4255be3a9b51651d3ac6 |
| Source note | uspto-grants-1988_12 |