Hydrochloric Acid → HCID 14894147, compound

HRID 414080Notes

Reaction equation

HRID 414080 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH:14][C:15](=[O:27])[C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[C:18]([Br:24])[C:17]=1[O:25]C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>CCO>[ClH:28].[CH2:1]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH:14][C:15](=[O:27])[C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[C:18]([Br:24])[C:17]=1[OH:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21282686HCID 21282686, compound

Product 1

HCID 14894147HCID 14894147, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from (-)-N-benzyl-2-(3-bromo-2,6-dimethoxybenzamidomethyl)pyrrolidine by dealkylation in the same manner as described in Example 2. Yield 55%. M.p. (HCl) 207°-209° C. (EtOH).

Sources & evidence

ORD record
ord-2b14a65405a848b78606da6959135edb
Source dataset
uspto-grants-1988_12
Patent number
US04789683

Reaction notes

Loading…