反应详情

8.45 g of 2-(2-pyridylthio)acetic acid (0.05 mole) and 10.6 g of 4-benzoyl-1,2-phenylenediamine (0.05 mole) in 100 ml of 4N hydrochloric acid are heated under reflux for 2 days. The mixture is allowed to cool and is neutralized with ammonia solution. It is extracted with ethyl acetate (3×100 ml), and the extract dried (Na2SO4), filtered and concentrated to a volume of 125 ml. From this solution, 11.7 g (68%) of 5-benzoyl-2-(2-pyridylthiomethyl)benzimidazole crystallize. The product thereby obtained is identical to that obtained by Method A, and the data for the identification appeat in Tables 1 and 2.

1. temperatureunder reflux for 2 days
2. temperatureto cool
3. extractionIt is extracted with ethyl acetate (3×100 ml)
4. dry with materialthe extract dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated to a volume of 125 ml
7. customFrom this solution, 11.7 g (68%) of 5-benzoyl-2-(2-pyridylthiomethyl)benzimidazole crystallize
8. customThe product thereby obtained
9. customthat obtained by Method A