1-Methylpiperazine → HCID 20098377, compound

HRID 414198Notes

Reaction equation

HRID 414198 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=1[C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][NH:15]2)=[O:9].[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>C(O)C>[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]2[CH:23]=[CH:22][CH:21]=[CH:20][C:7]=2[C:8]([NH:10][C:11]2[CH:19]=[CH:18][CH:17]=[C:16]3[C:12]=2[CH:13]=[CH:14][NH:15]3)=[O:9])[CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 15611138HCID 15611138, compound

Product 1

HCID 20098377HCID 20098377, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.8 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide in 36 ml of ethanol and 6.5 ml of N-methyl piperazine was refluxed for 1 hour and the solvents were eliminated under reduced pressure. The residue was chromatographed over silica (eluent: chloroform-ethanol, 9-1) to obtain 1.77 g of 2-[3-(4-methyl-1-piperazinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide.

Workup

  1. customThe residue was chromatographed over silica (eluent: chloroform-ethanol, 9-1)

Sources & evidence

ORD record
ord-8676cffa9d1f407190d8a5a8f686609c
Source dataset
uspto-grants-1988_12
Patent number
US04791109

Reaction notes

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