Sodium Carbonate → HCID 137225433, compound

HRID 414219Notes

Reaction equation

Cl.[NH2:2][OH:3].C(=O)([O-])[O-].[Na+].[Na+].[CH3:10][C:11]1[C:17](=[O:18])[C:16]2[N:19]3[C@@:23]([O:30][CH3:31])([C@H:24]([CH2:25][O:26][C:27]([NH2:29])=[O:28])[C:15]=2[C:13](=[O:14])[C:12]=1OC)[C@H:22]1[N:32]([CH3:33])[C@H:21]1[CH2:20]3>>[NH2:29][C:27]([O:26][CH2:25][CH:24]1[C:15]2[C:13]([OH:14])=[C:12]([N:2]=[O:3])[C:11]([CH3:10])=[C:17]([OH:18])[C:16]=2[N:19]2[CH2:20][CH:21]3[N:32]([CH3:33])[CH:22]3[C:23]12[O:30][CH3:31])=[O:28]

Participants

Reactant 3

HCID 10340Sodium Carbonate

HCID 159845(6,8a-Dimethoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl hydrogen carbonimidate

HCID 443297Hydroxyamine hydrochloride

Product 1

HCID 137225433HCID 137225433, compoundYield 97.7%

Procedure

In a similar manner to that described in Example 1, hydroxylamine hydrochloride (0.038 g), anhydrous sodium carbonate (0.033 g) and mitomycin F (0.100 g) are used to obtain the desired product (0.098 g; yield 87.0%).

Sources & evidence

ORD record: ord-f11a9063a3cb49f398d8b60e095bc9e5
Source dataset: uspto-grants-1988_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04791113

Reaction notes

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