Sodium Hydroxide → HCID 21282002, compound

HRID 414225Notes

Reaction equation

HRID 414225 reaction equation
Cl.[NH2:2][CH2:3][C:4]([C:6]1[S:7][C:8]([CH3:11])=[CH:9][CH:10]=1)=[O:5].[F:12][C:13]([F:28])([F:27])[C:14]1[CH:15]=[C:16]([CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:17](Cl)=[O:18].[OH-].[Na+]>C(Cl)Cl>[CH3:11][C:8]1[S:7][C:6]([C:4](=[O:5])[CH2:3][NH:2][C:17](=[O:18])[C:16]2[CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=[C:14]([C:13]([F:12])([F:27])[F:28])[CH:15]=2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 135833042-Amino-1-(5-methylthiophen-2-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 21282002HCID 21282002, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to Example 1, the reaction of 2-amino-1-(5-methylthienyl)ethanone hydrochloride (2.6 g, 0.014 mole) in methylene chloride (75 ml) with 3,5-bis(trifluoromethyl)benzoyl chloride (3.8 g, 0.014 mole) and 2N sodium hydroxide solution (13.7 ml) yielded 4.6 g of N-[2-(5-methylthienyl)-2-oxoethyl]-3,5-bis(trifluoromethyl)benzamide as a solid.

Sources & evidence

ORD record
ord-c15b897c09b0466a8e7d04eff015e694
Source dataset
uspto-grants-1988_12
Patent number
US04791124

Reaction notes

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