反应详情

To a stirred solution of 2-thiophenethiocarboxamide (1.56 g, 0.0109 mole) in ethanol (50 mL) was added 2-bromoacetophenone (2.19 g, 0.0110 mole). After complete addition the mixture was heated at reflux for two hours, then was allowed to cool to room temperature and stir for approximately 18 hours. The solvent was removed from the reaction mixture by evaporation under reduced pressure, leaving an oil which solidified. This solid was suspended in water and extracted twice with methylene chloride. The extracts were combined, dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure to yield 2.48 g of 4-phenyl-2-(thien-2-yl)thiazole as a solid, mp 51°-53° C.

1. additionAfter complete addition the mixture
2. temperaturewas heated
3. temperatureat reflux for two hours
4. customThe solvent was removed from the reaction mixture by evaporation under reduced pressure
5. customleaving an oil which
6. extractionextracted twice with methylene chloride
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered
9. customThe filtrate was evaporated under reduced pressure