HCID 14426225, compound → HCID 14426227, compound

HRID 414238Notes

Reaction equation

HRID 414238 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([C:25]2[O:26][C:27]([CH2:30][CH3:31])=[N:28][N:29]=2)([N:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].CO>[CH2:30]([C:27]1[O:26][C:25]([C:11]2([N:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:29][N:28]=1)[CH3:31]

Participants

5

Reactant 2

HCID 14426225HCID 14426225, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14426227HCID 14426227, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 1-benzyl-4-(ethyl-1,3,4-oxadiazolyl)-4-(N-phenylpropionamido)piperidine (8.20 g, 19.6 mmol) and 10% palladium on charcoal (2.0 g) in methanol (100 ml) was reacted with hydrogen (50 psi) in a Parr shaker. After 24 hours, the resulting mixture was filtered and the filtrate was concentrated in vacuo. A foamy residue (6.42 g, 19.5 mmol) was obtained. It was used for reactions without further purification. ##STR32##

Workup

  1. filtrationthe resulting mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-73179590671a46d6a2322c87c34d9e10
Source dataset
uspto-grants-1988_12
Patent number
US04791120

Reaction notes

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