反应详情

4.0 g of 2-sec-butylthio-4-methylsulfonyloxy-1,3-thiazole was dissolved in 15 ml of acetic acid, and 2.2 ml of 35% aqueous hydrogen peroxide was added to the solution at room temperature, followed by reaction at 30° to 40° C. for 4 hours. The reaction mixture was poured into chilled water, neutralized by 5% aqueous solution of sodium hydroxide, and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of common salt, dried over anhydrous sodium sulfate and concentrated to obtain an oil, which was purified by silica-gel column chromatography to 2.1 g of the objective compound as a pale yellow oil (yield: 49.7%).

1. customfollowed by reaction at 30° to 40° C. for 4 hours
2. additionThe reaction mixture was poured
3. extractionextracted with ethyl acetate
4. washThe extract was washed with a saturated aqueous solution of common salt
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. customto obtain an oil, which