反应详情

温度

0 °C

A mixture of phosphorus tribromide (2.1 g) and toluene (1 cm3) was added dropwise to a solution of 2,3,4,5,6-pentafluorobenzylalcohol (3.4 g) and pyridine (0.21 g) in toluene (10 cm3) at 0° C. The reaction mixture was stirred at 0° C. for 45 minutes, then at the ambient temperature (ca. 20° C.) for 75 minutes, and was then added to an excess of saturated sodium bicarbonate solution. The products were extracted into diethyl ether, and the combined ether layers dried and concentrated by evaporation under reduced pressure. The residual solution (still containing toluene) was passed through a plug of silica gel.

1. waitat the ambient temperature (ca. 20° C.) for 75 minutes
2. extractionThe products were extracted into diethyl ether
3. dry with materialthe combined ether layers dried
4. concentrationconcentrated by evaporation under reduced pressure