HCID 21282302, compound → HCID 21282313, compound

HRID 414312Notes

Reaction equation

HRID 414312 reaction equation
[CH2:1]([N:5]([CH2:27]CCC)[CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[N:17]=[C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[S:19][CH:20]=1)[CH2:2]CC.ClC1C=CC(C2SC=C(C3C=CC=CC=3OCCCN(CCCC)CCCC)[N:42]=2)=CC=1>>[N:5]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]2[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[S:19][CH:20]=2)[CH:1]=[CH:2][N:42]=[CH:27]1

Participants

3

Reactant 2

HCID 21282302HCID 21282302, compoundHCID 21282310HCID 21282310, compound

Product 1

HCID 21282313HCID 21282313, compound

Procedure

By substituting m-hydroxyacetophenone for the p-hydroxyacetophenone, p-hydroxypropiophenone or p-hydroxybutyrophenone of Examples 1-26, the corresponding 4-(3-aminoalkoxyphenyl)-2-substituted thiazoles are produced. For example, 4-(3-dibutylaminopropoxyphenyl)-2-phenylthiazole, 4-[3-(4-methylpiperazol-1-yl)propoxyphenyl]-2-phenylthiazole and 2-(4-chlorophenyl)-4-(3-dibutylaminopropoxyphenyl)thiazole are produced by using m-hydroxyacetophenone in Examples 1, 6 and 16, respectively.

Sources & evidence

ORD record
ord-2ad310a3efc5481492c3e28d450698ec
Source dataset
uspto-grants-1988_12
Patent number
US04791200

Reaction notes

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