HCID 21282302, compound → HCID 21282313, compound

Participants

Reaction Steps

By substituting m-hydroxyacetophenone for the p-hydroxyacetophenone, p-hydroxypropiophenone or p-hydroxybutyrophenone of Examples 1-26, the corresponding 4-(3-aminoalkoxyphenyl)-2-substituted thiazoles are produced. For example, 4-(3-dibutylaminopropoxyphenyl)-2-phenylthiazole, 4-[3-(4-methylpiperazol-1-yl)propoxyphenyl]-2-phenylthiazole and 2-(4-chlorophenyl)-4-(3-dibutylaminopropoxyphenyl)thiazole are produced by using m-hydroxyacetophenone in Examples 1, 6 and 16, respectively.

Provenance & Evidence