Thionyl Chloride → 3-Bromo-2-chloro-4,5-difluorobenzoyl chloride

HRID 414369Notes

Reaction equation

HRID 414369 reaction equation
[Br:1][C:2]1[C:3]([Cl:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[C:3]([Cl:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 98383473-Bromo-2-chloro-4,5-difluorobenzoic acid

Product 1

HCID 140717973-Bromo-2-chloro-4,5-difluorobenzoyl chloride

Procedure

A solution of 3-bromo-2-chloro-4,5-difluorobenzoic acid (9.0 g) in thionyl chloride (33 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation to give the title compound (8.8 g), bp 109° C./22 mmHg.

Workup

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation

Sources & evidence

ORD record
ord-18d29e282d0a4a95baf47415037746ea
Source dataset
uspto-grants-1988_12
Patent number
US04791225

Reaction notes

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