反应详情

10 g of Norfloxacin were added to 20 ml of ethanol, the mixture obtained was then stirred and heated to reflux. 4.2 g of nicotinic acid, previously dissolved in 5 ml of hot ethanol, were added in one portion to said mixture and the resulting suspension was heated to reflux, upon which all solids dissolved. After a short time at reflux the adduct began to separate. The mixture was stirred, cooled to room temperature and finally in an ice bath to yield the nicotinic acid-Norfloxacin 1:1 adduct in 88% yield; m.p. 232°-233° C.

1. customthe mixture obtained
2. temperatureheated to reflux
3. additionwere added in one portion
4. temperaturethe resulting suspension was heated
5. temperatureto reflux, upon which all solids
6. dissolutiondissolved
7. temperatureAfter a short time at reflux the adduct
8. customto separate
9. stirringThe mixture was stirred