Hydrochloric Acid → HCID 178482277, compound

HRID 414449Notes

Reaction equation

HRID 414449 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.C(O)C.[CH3:19][NH2:20].Cl>C(O)C>[CH3:19][NH:20][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 22028356Methylamine ethanolHCID 178522716HCID 178522716, compound

Product 1

HCID 178482277HCID 178482277, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 2.26 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 30 ml of ethanol, 6.50 ml of 30%-methylamine ethanol solution was added, and the mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.57 g of the desired compound as pale yellow needles, m.p. 260° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.57 g of the desired compound as pale yellow needles, m.p. 260° C. (decomp.)

Sources & evidence

ORD record
ord-a080809fd9bb4687a8fe9da4e2cc1bd0
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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