反应详情

To a suspension of 2.26 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 30 ml of ethanol, 6.50 ml of 30%-methylamine ethanol solution was added, and the mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.57 g of the desired compound as pale yellow needles, m.p. 260° C. (decomp.).

1. additionwas added
2. temperaturethe mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube
3. filtrationThe precipitate was collected by filtration
4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.57 g of the desired compound as pale yellow needles, m.p. 260° C. (decomp.)