Hydrochloric Acid → HCID 178463351, compound

HRID 414450Notes

Reaction equation

HRID 414450 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.[CH2:16]([NH2:18])[CH3:17].Cl>C(O)C>[CH2:16]([NH:18][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1)[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6341EthylamineHCID 178522716HCID 178522716, compound

Product 1

HCID 178463351HCID 178463351, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 2.26 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 30 ml of ethanol, 4.05 ml of 70%-ethylamine aqueous solution was added, and the mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.66 g of the desired compound as pale yellow needles, m.p. 272°-273.5 ° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.66 g of the desired compound as pale yellow needles, m.p. 272°-273.5 ° C. (decomp.)

Sources & evidence

ORD record
ord-b722fb99da1e4f798a35ec2ce087fa26
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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