Hydrochloric Acid → HCID 178456802, compound

HRID 414451Notes

Reaction equation

HRID 414451 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.Cl>C(O)C.C(N)(C)C>[CH:6]([NH:7][C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1)([CH3:8])[CH3:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178522716HCID 178522716, compound

Product 1

HCID 178456802HCID 178456802, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6363IsopropylamineSolvent

Procedure

To a suspension of 2.26 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 30 ml of ethanol, 4.26 ml of isopropylamine was added, and the mixture was heated for 44 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.36 g of the desired compound as pale yellow needles, m.p. 272°-274 ° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was heated for 44 hours at 80°-90 ° C. in a sealed tube
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.36 g of the desired compound as pale yellow needles, m.p. 272°-274 ° C. (decomp.)

Sources & evidence

ORD record
ord-b34db6b099004087952dbcf024417799
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

Loading…