HCID 178522716, compound → HCID 178463858, compound

HRID 414453Notes

Reaction equation

HRID 414453 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1>C1C=CC=CC=1.C(NCC)C>[CH2:3]([N:4]([CH2:5][CH3:6])[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1)[CH3:2]

Participants

4

Reactant 1

HCID 178522716HCID 178522716, compound

Product 1

HCID 178463858HCID 178463858, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8021DiethylamineSolvent

Procedure

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of benzene, 20 ml of diethylamine was added, and the mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was evaporated. Water was added to the residue, and then the aqueous solutron was adjusted with dilute hydrochloric acid to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 0.75 g of the desired compound as yellow plates, m.p. 217°-218 ° C.

Workup

  1. additionwas added
  2. temperaturethe mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube
  3. customThe reaction mixture was evaporated
  4. additionWater was added to the residue
  5. filtrationThe precipitate was collected by filtration
  6. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 0.75 g of the desired compound as yellow plates, m.p. 217°-218 ° C.

Sources & evidence

ORD record
ord-c8580e301ce54edfa4a0dc9e9be1943c
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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