反应详情

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of benzene, 20 ml of diethylamine was added, and the mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube. The reaction mixture was evaporated. Water was added to the residue, and then the aqueous solutron was adjusted with dilute hydrochloric acid to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 0.75 g of the desired compound as yellow plates, m.p. 217°-218 ° C.

1. additionwas added
2. temperaturethe mixture was heated for 24 hours at 80°-90 ° C. in a sealed tube
3. customThe reaction mixture was evaporated
4. additionWater was added to the residue
5. filtrationThe precipitate was collected by filtration
6. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 0.75 g of the desired compound as yellow plates, m.p. 217°-218 ° C.