反应详情

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of benzene, 2.96 ml of 4-methylpiperidine was added, and the mixture was refluxed for 5 hours. The reaction mixture was evaporated, ethanol was added to the residue, and then the ethanol solution was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.02 g of the desired compound as yellow columns, m.p. 246.5°-248.5° C. (decomp.).

1. additionwas added
2. temperaturethe mixture was refluxed for 5 hours
3. customThe reaction mixture was evaporated
4. additionethanol was added to the residue
5. filtrationThe precipitate was collected by filtration
6. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.02 g of the desired compound as yellow columns, m.p. 246.5°-248.5° C. (decomp.)