Hydrochloric Acid → HCID 178522721, compound

Participants

Reaction Steps

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of ethanol, 1.52 g of 4-hydroxypiperidine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.00 g of the desired compound as pale yellow crystals, m.p. 259.5°-261° C. (decomp.).

Provenance & Evidence