Hydrochloric Acid → HCID 178522721, compound

HRID 414459Notes

Reaction equation

HRID 414459 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH:10][C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[O:9])[CH:5]=[N:4][CH:3]=1.[OH:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl>C(O)C>[OH:16][CH:17]1[CH2:22][CH2:21][N:20]([C:2]2[N:7]=[C:6]([C:8]([NH:10][C:11]3[NH:15][N:14]=[N:13][N:12]=3)=[O:9])[CH:5]=[N:4][CH:3]=2)[CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79341Piperidin-4-olHCID 178522716HCID 178522716, compound

Product 1

HCID 178522721HCID 178522721, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 20 ml of ethanol, 1.52 g of 4-hydroxypiperidine was added, and the mixture was refluxed for 6 hours. The reaction mixture was adjusted with ethanolic hydrogen chloride to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylsulfoxide and methanol affording 1.00 g of the desired compound as pale yellow crystals, m.p. 259.5°-261° C. (decomp.).

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for 6 hours
  3. filtrationThe precipitate was collected by filtration
  4. customrecrystalized from a mixture of dimethylsulfoxide and methanol affording 1.00 g of the desired compound as pale yellow crystals, m.p. 259.5°-261° C. (decomp.)

Sources & evidence

ORD record
ord-34036c81c8444bf7979a4b05961db65c
Source dataset
uspto-grants-1988_12
Patent number
US04792547

Reaction notes

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