反应详情

2-(9-Anthryloxy)ethyl chloride (5.0 g) was heated for 5 hours at 90° C. in methylene glycol (50 ml) containing dimethylamine (4.0 g) using a dry ice condenser. The solution was cooled and added to water. The resulting mixture was extracted with ethyl acetate, and the extract dried and evaporated. The crude product was chromatographed on 100 g silica gel, eluting with a solution of methylene chloride:methanol:ammonium hydroxide, 95:5:1, to yield 1-(9-anthryloxy)-2-dimethylaminoethane, which was converted to the maleate, mp 132°-134° C.

1. temperatureThe solution was cooled
2. extractionThe resulting mixture was extracted with ethyl acetate
3. customthe extract dried
4. customevaporated
5. customThe crude product was chromatographed on 100 g silica gel
6. washeluting with a solution of methylene chloride