Sodium Hydroxide → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

HRID 414570Notes

Reaction equation

HRID 414570 reaction equation
Cl.[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1.[OH-].[Na+]>C(Cl)Cl>[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 198547386-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

Product 1

HCID 143732856-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of 1.0 g of 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride in 100 ml of methylene chloride is stirred with a twofold stoichiometric excess of dilute aqueous sodium hydroxide solution until the salt is completely dissolved. The organic layer is separated, washed with water, dried over magnesium sulfate and evaporated to yield 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is separated
  3. washwashed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-f6c4dc47c8094a44bf0be7a887ad6437
Source dataset
uspto-grants-1988_12
Patent number
US04792561

Reaction notes

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