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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 414570Generated: October 26, 2026

Sodium Hydroxide → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

https://huagongshe.com/reaction/414570

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochlorideHCID 19854738—
SolventDichloromethaneHCID 6344—
Product6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyrilHCID 14373285—

Reaction Steps

A suspension of 1.0 g of 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride in 100 ml of methylene chloride is stirred with a twofold stoichiometric excess of dilute aqueous sodium hydroxide solution until the salt is completely dissolved. The organic layer is separated, washed with water, dried over magnesium sulfate and evaporated to yield 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril as the free base.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04792561
Source datasetuspto-grants-1988_12
ORD IDord-f6c4dc47c8094a44bf0be7a887ad6437
Source noteuspto-grants-1988_12