反应详情

温度

25 °C

To a mixture of 2,6-dimethyl-4-bromoanisole (4.14 g) and tetrakis (triphenylphosphine) palladium (0.69 g) in toluene (40 ml) and 2.0 molar aqueous sodium carbonate (20 ml) was added phenylboric acid (2. 7 g) in ethanol (10 ml). The reaction was heated at reflux for 16 hours, at which time a solution of phenylboric acid (1.0 g) in ethanol (3 ml) was added. The reaction was heated at reflux for a further 6 hours and then cooled to 25° C., and 30% hydrogen peroxide (1.0 ml) was added. The mixture was stirred for one hour, then poured into water and extracted with ether. The organic phase was dried and evaporated and the residue was chromatographed on silica gel, eluting with 9:1 hexane either, so as to afford 2,6-dimethyl-4-methoxybiphenyl.

1. temperatureThe reaction was heated
2. additionwas added
3. temperatureThe reaction was heated
4. temperatureat reflux for a further 6 hours
5. extractionextracted with ether
6. customThe organic phase was dried
7. customevaporated
8. customthe residue was chromatographed on silica gel
9. washeluting with 9:1 hexane either