反应详情

2,6-dimethyl-4-methoxybiphenyl (3.0 g), acetic acid (30 ml) and 48% aqueous hydrobromic acid (30 ml) were heated at reflux temperature for 4 hours. The mixture was then cooled, poured into water and extracted with ether. After extracting the organic solution with aqueous sodium hydroxide, the aqueous extract was acidified with aqueous hydrochloric acid and further extracted with ether. The resulting extract was dried and evaporated and the residue was recrystallized from acetone/hexane to afford 2,6-dimethyl-4-hydroxybiphenyl, mp 128°-130° C.

1. temperatureat reflux temperature for 4 hours
2. temperatureThe mixture was then cooled
3. extractionextracted with ether
4. extractionAfter extracting the organic solution with aqueous sodium hydroxide
5. extractionthe aqueous extract
6. extractionfurther extracted with ether
7. extractionThe resulting extract
8. customwas dried
9. customevaporated
10. customthe residue was recrystallized from acetone/hexane