Diethyl Ether → HCID 14424685, compound

Temperature

23 °C

To a solution of 0.12 mol of ethynylmagnesium bromide in 300 mL of dry THF at 23° C. was added 15.5 g (90 mmol) of 2-chloro-4'-fluoro-acetophenone as a solid. The mixture stirred at 23° C. for 24 hours when it was quenched with 15 mL of saturated NH4Cl and poured int 250 mL of diethyl ether. The ether layer was separated and washed with H2O, dried (MgSO4) and concentrated. The residue was added to 300 mL of dry diethyl ether and 3.6 g (90 mmol) of pulverized NaOH was added. The reaction mixture was stirred at 23° C. for 3 hours, then the ether was washed twice with 100 mL of H2O and once with saturated brine. The organic layer was dried (MgSO4), concentrated and distillation (b.p. 55°-58° C. at 0.34 mmHg) provided 9.5 g (66%) of 3,4-epoxy- 3-(4'-fluorophenyl)-1-butyne as a liquid, homogeneous by spectroscopic criteria; IR (film) 3275, 1595, 1505, 1218 cm-1 ; 1HNMR (80 MHz, CDCl3) δ 7.45 (m, 2H), 7.15 (m, 2H), 3.20 (ABq, 2H, J=8.0 Hz, ΔνAB =39.2 Hz), 2.51 (s, 1H).

1. customwas quenched with 15 mL of saturated NH4Cl
2. additionpoured int 250 mL of diethyl ether
3. customThe ether layer was separated
4. washwashed with H2O
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. additionwas added
8. stirringThe reaction mixture was stirred at 23° C. for 3 hours
9. washthe ether was washed twice with 100 mL of H2O and once with saturated brine
10. dry with materialThe organic layer was dried (MgSO4)
11. concentrationconcentrated
12. distillationdistillation (b.p. 55°-58° C. at 0.34 mmHg)

ORD record

ord-e9334638a62c4c89ab9d70a09edeb036

Source dataset

uspto-grants-1988_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04792614