Hydrochloric Acid → 1-Amino-7-hydroxy-6-iodo-4-methylindane hydrochloride

Participants

Reaction Steps

One gram of 1-amino-7-hydroxy-4-methylindane hydrochloride was dissolved in 20 ml of water, then 5 ml of 3N-hydrochloric acid solution containing 0.85 g of iodine monochloride was added dropwise at a room temperature under vigorous stirring condition. The reaction mixture was stirred at the same temperature for 2 hours, then ice-cooled. The crystals precipitated were collected by filtration, and changed them to hydrochloride, washed with ether and dried. 0.70 Grams of 1-amino-7-hydroxy-6-iodo-4-methylindane hydrochloride was obtained in the form of yellow needle-like crystals. Melting point: Over 200° C. (decomp.).

Provenance & Evidence