Hydrochloric Acid → 1-Amino-7-hydroxy-6-iodo-4-methylindane hydrochloride

HRID 414688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414688
[ClH:1].[NH2:2][CH:3]1[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[CH:9][C:10]=2[OH:12])[CH2:5][CH2:4]1.Cl.[I:15]Cl>O>[ClH:1].[NH2:2][CH:3]1[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[C:9]([I:15])[C:10]=2[OH:12])[CH2:5][CH2:4]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24640Iodine chlorideHCID 136041701-Amino-7-hydroxy-4-methylindane hydrochloride

Produkt 1

HCID 133768461-Amino-7-hydroxy-6-iodo-4-methylindane hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

One gram of 1-amino-7-hydroxy-4-methylindane hydrochloride was dissolved in 20 ml of water, then 5 ml of 3N-hydrochloric acid solution containing 0.85 g of iodine monochloride was added dropwise at a room temperature under vigorous stirring condition. The reaction mixture was stirred at the same temperature for 2 hours, then ice-cooled. The crystals precipitated were collected by filtration, and changed them to hydrochloride, washed with ether and dried. 0.70 Grams of 1-amino-7-hydroxy-6-iodo-4-methylindane hydrochloride was obtained in the form of yellow needle-like crystals. Melting point: Over 200° C. (decomp.).

Aufarbeitung

  1. additionwas added dropwise at a room temperature under vigorous stirring condition
  2. temperatureice-cooled
  3. customThe crystals precipitated
  4. filtrationwere collected by filtration
  5. washwashed with ether
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4bf3dff9e2414178aa2868915dea8488
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04792628

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