Hydrochloric Acid → HCID 14392046, compound

Participants

Reaction Steps

1.77 Grams of 1-amino-4,6-dimethyl-7-hydroxyindane was dissolved in 100 ml of 0.2N-sodium hdyroxide aqueous solution, then 1.7 g of α-chloroacetyl chloride was added thereto under an ice-cooling condition. Then the reaction mixture was stirred at a room temperature for 2 hours. The reaction mixture was acidified by adding a diluted hydrochloric acid, then extracted with chloroform. The chloroform layer was washed with water, dried, then the solvent was removed by evaporation. Recrystallized from ethanol to obtain 2.34 g of 1-acetylamino-4,6-dimethyl-7-hydroxyindane in the form of colorless needle-like crystals. Melting point: 131°-132° C.

Provenance & Evidence