Hydrochloric Acid → HCID 14392046, compound

HRID 414691Notes

Reaction equation

HRID 414691 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[C:6]([CH3:13])[CH:7]=[C:8]([CH3:12])[C:9]=2[OH:11])[CH2:4][CH2:3]1.Cl[CH2:15][C:16](Cl)=[O:17].Cl>[Na]>[C:16]([NH:1][CH:2]1[C:10]2[C:5](=[C:6]([CH3:13])[CH:7]=[C:8]([CH3:12])[C:9]=2[OH:11])[CH2:4][CH2:3]1)(=[O:17])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 12857262HCID 12857262, compound

Product 1

HCID 14392046HCID 14392046, compound

Reagents, catalysts & solvents 1

HCID 5360545SodiumSolvent

Procedure

1.77 Grams of 1-amino-4,6-dimethyl-7-hydroxyindane was dissolved in 100 ml of 0.2N-sodium hdyroxide aqueous solution, then 1.7 g of α-chloroacetyl chloride was added thereto under an ice-cooling condition. Then the reaction mixture was stirred at a room temperature for 2 hours. The reaction mixture was acidified by adding a diluted hydrochloric acid, then extracted with chloroform. The chloroform layer was washed with water, dried, then the solvent was removed by evaporation. Recrystallized from ethanol to obtain 2.34 g of 1-acetylamino-4,6-dimethyl-7-hydroxyindane in the form of colorless needle-like crystals. Melting point: 131°-132° C.

Workup

  1. temperatureunder an ice-cooling condition
  2. extractionextracted with chloroform
  3. washThe chloroform layer was washed with water
  4. customdried
  5. customthe solvent was removed by evaporation
  6. customRecrystallized from ethanol

Sources & evidence

ORD record
ord-e6aaac1f6f3c48cfa49e1d1c9820d97a
Source dataset
uspto-grants-1988_12
Patent number
US04792628

Reaction notes

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