Hydrochloric Acid → HCID 21281601, compound

HRID 414695Notes

Reaction equation

HRID 414695 reaction equation
[ClH:1].[NH2:2][CH:3]1[C:11]2[C:6](=[C:7](C)[CH:8]=[C:9]([CH2:13][NH:14]C(=O)C[Cl:17])[C:10]=2[OH:12])[CH2:5][CH2:4]1.Cl.[CH2:21](O)C>>[ClH:17].[ClH:1].[NH2:2][C:3]1([CH3:21])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:13][NH2:14])[C:10]=2[OH:12])[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 13604172HCID 13604172, compound

Product 1

HCID 21281601HCID 21281601, compound

Procedure

5 Grams of 1-amino-4-methyl-6-α-chloroacetylaminomethyl-7-hydroxyindane hydrochloride and 100 ml of ethanol containing 50 ml of concentrated hydrochloric acid were refluxed by heating for 8 hours. The solvent was removed by evaporation and the residue obtained was washed with ethanol. Recrystallized from methanol-ether to obtain 1 g of 1-amino-methyl-6-aminomethyl-7-hydroxyindane dihydrochloride.

Workup

  1. temperatureby heating for 8 hours
  2. customThe solvent was removed by evaporation
  3. customthe residue obtained
  4. washwas washed with ethanol
  5. customRecrystallized from methanol-ether

Sources & evidence

ORD record
ord-effafe050bbf4061b0110b4366a34e29
Source dataset
uspto-grants-1988_12
Patent number
US04792628

Reaction notes

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