Water → HCID 10429612, compound

HRID 414709Notes

Reaction equation

HRID 414709 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]1[C:11]2=[CH:12][CH:13]=[CH:14][N:10]2[CH:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]=2[O:6]1)C.C(=O)([O-])[O-].[K+].[K+].Cl[C:32]([O:34][CH2:35][CH3:36])=[O:33].O>C1C=CC=CC=1>[CH2:35]([O:34][C:32]([N:2]([CH2:4][CH:5]1[C:11]2=[CH:12][CH:13]=[CH:14][N:10]2[CH:9]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:8]2[CH:21]=[CH:22][CH:23]=[CH:24][C:7]=2[O:6]1)[CH3:1])=[O:33])[CH3:36]

Participants

6

Reactant 4

HCID 962WaterHCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 10358515HCID 10358515, compound

Product 1

HCID 10429612HCID 10429612, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
65 °C

Procedure

To a mixture of 11-dimethylaminomethyl-5-phenyl-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (9.92 g) and potassium carbonate (4.28 g) in 150 ml of benzene was added ethyl chloroformate (5.9 ml). This was heated at 65° C. for 6 hours, then added to water and extracted with ethyl ether (4×). The combined organics were washed with water, dried and concentrated to give 10.5 g of an oil which was used without further purification.

Workup

  1. extractionextracted with ethyl ether (4×)
  2. washThe combined organics were washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-e6d1ad8431de451aa03abdfdf65ba04c
Source dataset
uspto-grants-1988_12
Patent number
US04794110

Reaction notes

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