Sodium Hydroxide → HCID 23675389, compound

HRID 414722Notes

Reaction equation

HRID 414722 reaction equation
[OH-].[Na+:2].[CH3:3][C:4]([CH3:26])([CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:21]=[C:22]([CH3:25])[S:23][CH:24]=2)=[CH:16][CH:15]=1)[C:5]([O:7]CC)=[O:6]>C(O)C>[CH3:3][C:4]([CH3:26])([CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[N:21]=[C:22]([CH3:25])[S:23][CH:24]=2)=[CH:16][CH:15]=1)[C:5]([O-:7])=[O:6].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14349173HCID 14349173, compound

Product 1

HCID 23675389HCID 23675389, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 5 ml of ethanol was dissolved in 1.40 g of ethyl 2,2-dimethyl-5-[p-(2-methyl-4-thiazolyl)phenoxy]pentanoate obtained in EXAMPLE 5. The solution was added to an aqueous sodium hydroxide solution (0.4 g of sodium hydroxide in 5 ml of water) and the mixture refluxed for 10 hours. After cooling, the precipitated crystals was washed with water to obtain the desired product, sodium 2,2-dimethyl-5-[p-(2-methyl-4-thiazolyl)phenoxy]pentanoate as white crystals.

Workup

  1. temperaturethe mixture refluxed for 10 hours
  2. temperatureAfter cooling
  3. washthe precipitated crystals was washed with water

Sources & evidence

ORD record
ord-e9dff706ab2d448082dceaf2421351e0
Source dataset
uspto-grants-1988_12
Patent number
US04794113

Reaction notes

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