Hydrochloric Acid → 4-(1H-Tetrazol-1-yl)butanoic acid

HRID 414745Notes

Reaction equation

HRID 414745 reaction equation
C([O:3][C:4](=[O:13])[CH2:5][CH2:6][CH2:7][N:8]1[CH:12]=[N:11][N:10]=[N:9]1)C.Cl.O>C(O)(=O)C>[N:8]1([CH2:7][CH2:6][CH2:5][C:4]([OH:13])=[O:3])[CH:12]=[N:11][N:10]=[N:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 54380935HCID 54380935, compound

Product 1

HCID 229965434-(1H-Tetrazol-1-yl)butanoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6.65 g of 4-(tetrazol-1-yl)-butyric acid ethyl ester are stirred in 42.7 ml of acetic acid, 8.1 ml of concentrated HCl and 17.2 ml of water for 3 hours at 100°. After cooling, the reaction mixture is concentrated three times each with toluene and ether under reduced pressure in a rotary evaporator. After drying under a high vacuum, the title compound is obtained.

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture is concentrated three times each with toluene and ether under reduced pressure
  3. customin a rotary evaporator
  4. customAfter drying under a high vacuum

Sources & evidence

ORD record
ord-add67cccdb0043369f740c7045012753
Source dataset
uspto-grants-1988_12
Patent number
US04794109

Reaction notes

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