Thionyl Chloride → 5-(Tetrazol-1-yl)-valeric acid chloride

HRID 414750Notes

Reaction equation

HRID 414750 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[CH:5]=[N:4][N:3]=[N:2]1.S(Cl)([Cl:15])=O>C1C=CC=CC=1.CN(C=O)C>[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([Cl:15])=[O:12])[CH:5]=[N:4][N:3]=[N:2]1

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 212802905-(1H-Tetrazol-1-yl)pentanoic acid

Product 1

HCID 178034065-(Tetrazol-1-yl)-valeric acid chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 241BenzeneSolvent

Procedure

1 g of 5-(tetrazol-1-yl)-valeric acid is heated for 20 minutes at reflux temperature in 12 ml of absolute benzene with 0.6 ml of thionyl chloride and 2 drops of DMF. After concentration by evaporation under reduced pressure, the title compound is obtained.

Workup

  1. concentrationAfter concentration
  2. customby evaporation under reduced pressure

Sources & evidence

ORD record
ord-ed7046e8954e4b1bbcaa5eb8decee603
Source dataset
uspto-grants-1988_12
Patent number
US04794109

Reaction notes

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