反应详情

Chlorosulfonic acid (100 g.) was cooled to 0° C. and trifluoroacetanilide (30 g.) was added portionwise with vigorous stirring keeping the temperature below +5° C. The reaction was stirred at room temperature overnight, and cautiously poured onto ice. The white solid produced was filtered, washed copiously with water, and dried to give 4-trifluoroacetamido benzenesulfonyl chloride (39.14 gl)(m.r. 143°-146° C.).

1. customthe temperature below +5° C
2. stirringThe reaction was stirred at room temperature overnight
3. additioncautiously poured onto ice
4. customThe white solid produced
5. filtrationwas filtered
6. washwashed copiously with water
7. customdried