反应详情

温度

60 °C

A solution of 7,8-dimethoxy-1-hydroxy-2,3,4,5-tetrahydro-3-benzazepine (3 g, 13.4 mmole) in 25 ml dimethylformamide was slowly dropped into a stirring suspension of sodium hydride (50% oil dispersion, 0.7 g, 14.8 mmole), previously washed with hexane, in 10 ml dimethylformamide. After the addition was completed, the mixture was warmed for one hour at 60° C., then was cooled and a solution of 3,4-dichlorofluorobenzene (2.4 g, 14.8 mmole) in 10 ml dimethylformamide was added. After stirring two hours at ambient temperature, the reaction mixture was stirred with 400 ml water and was extracted with ethyl acetate. The organic extract was washed with ethyl acetate. The organic extract was washed with water and saturated NaCl and was dried (anhydrous MgSO4), filtered and evaporated to 7 g of an oil. This oil was purified by HPLC (silica gel, 5% methanol in dichloromethane) to give 2.8 g (57%) of an oil. This oil was converted to the oxalate salt as in Example 1 and was recrystallized from ethyl acetate-methanol to give 2.1 g (34%) of 1,(3-4-dichlorophenoxy)-7,8-dimethoxy-2,3,4,5-tetrahydro-3-benzazepine oxalate, d 167°-168° C.

1. washpreviously washed with hexane, in 10 ml dimethylformamide
2. additionAfter the addition
3. temperaturewas cooled
4. extractionwas extracted with ethyl acetate
5. extractionThe organic extract
6. washwas washed with ethyl acetate
7. extractionThe organic extract
8. washwas washed with water and saturated NaCl
9. dry with materialwas dried (anhydrous MgSO4)
10. filtrationfiltered
11. customevaporated to 7 g of an oil
12. customThis oil was purified by HPLC (silica gel, 5% methanol in dichloromethane)