反应详情

This ketone (1.2 g) was refluxed with 2-chloromethylquinoline hydrochloride (1.3 g), potassium carbonate (8.6 g), potassium iodide (0.05 g) and cesium carbonate (0.05 g) in acetone (300 ml) for 24 hours. The reaction mixture was filtered, and the filtrate was concentrated, dissolved in chloroform, and then washed with sodium hydroxide solution (5%), water and brine. After drying this solution over MgSO4, all volatiles were removed. The residue was purified by chromatography on silica gel (25% ethyl acetate in hexanes). The pure desired product was isolated as a tan solid, m.p. 52°-55° C.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate was concentrated
3. dissolutiondissolved in chloroform
4. washwashed with sodium hydroxide solution (5%), water and brine
5. dry with materialAfter drying this solution over MgSO4
6. customall volatiles were removed
7. customThe residue was purified by chromatography on silica gel (25% ethyl acetate in hexanes)