HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 414872Generated: October 29, 2026
Dimethylformamide → 3-Nitrophenoxyacetic acid methyl ester
https://huagongshe.com/reaction/414872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl chloroacetate | HCID 7295 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Nitrophenol | HCID 11137 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Nitrophenoxyacetic acid methyl ester | HCID 10703704 | — |
Reaction Steps
300 g of 3-nitrophenol are added to 800 ml of DMF. Then 240 g of sodium carbonate are added portionwise. Subsequently 270 g of chloroacetic acid methylester is added at 22° C. Then the mixture is stirred at 85° C. for six hours. After being cooled down to 25° C. it is given to 3 kg of water and 1 kg of ice. The resulting suspension is filtered off. The filter cake is washed with 300 g of water and dried in vacuum. Yield: 407 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08088182B2 |
|---|
| Source dataset | uspto-grants-2012_01 |
|---|
| ORD ID | ord-59738f8d68634a47b39d281b95697ed6 |
|---|
| Source note | uspto-grants-2012_01 |
|---|
